Hyperhidrosis research initiative

Hyperhidrosis isn’t just about sweating.

It’s the visible sign of a deeper neurological disorder rooted in the biochemistry and bioelectricity sodium channel (Nav1.7, 1.8, 1.9, etc.).

All current treatments only mask symptoms, never addressing the cause. The real solution lies in directly targeting the root cause, which will be the only path to a true cure for the majority of hyperhidrosis patients.

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The vicious loop
01
Sodium channel mutation
Nav1.7, 1.8, 1.9 and related channels carry a gain-of-function mutation.
02
Nerves fire too easily
The threshold for firing drops across sensory and autonomic nerves.
03
Sympathetic overactivation
The sympathetic nervous system is pushed into a constant overactive state.
04
Excessive sweating
Sweat glands are driven far beyond what thermoregulation requires.
05
Visceral anxiety and more
Anxiety and a variety of other symptoms close the loop and reinforce it.

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Explanations of the sodium channel mechanism, current treatments and where the search for a cure stands.

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